Neuropilins and use thereof in methods for diagnosis and prognosis of cancer

摘要

The present invention relates to VEGF receptors (VEGFR) and neuropilins such as VEGF165R/NP-1 and NP-2 that are associated with metastatic potential of a malignant cell and their use in the diagnosis and prognosis of cancer. Preferred ones are VEGF165R/NP-1 and NP-2 but any neuropilin or VEGFR, where the constituents share at least about 85 % homology with either of the above VEGF165R/NP-1 and NP-2 can be used. More preferably, such constituent shares at least 90 % homology. Still more preferably, each constituent shares at least 95 % homology.