发明名称 |
Synthesis of cc-1065/duocarmycin analogs |
摘要 |
The dihydroindole C-ring found in CC-1065/duocarmycin analogs is formed by the 5-exo-trig radical cyclization of an aryl halide onto a tethered vinyl chloride forming with chlorine installed as a suitable leaving group for subsequent cyclopropane spirocyclization. The versatility of this approach is disclosed in the context of six CC-1065/duocarmycin analogs previously synthesized in this laboratory. |
申请公布号 |
AU1807999(A) |
申请公布日期 |
1999.06.28 |
申请号 |
AU19990018079 |
申请日期 |
1998.12.08 |
申请人 |
THE SCRIPPS RESEARCH INSTITUTE |
发明人 |
DALE L BOGER |
分类号 |
C07B61/00;C07C271/16;C07C271/22;C07C271/28;C07D209/08;C07D209/10;C07D209/80;C07D215/54;C07D471/04;C07D487/04;C07D519/00 |
主分类号 |
C07B61/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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