| 发明名称 |
Diphtheria toxin vaccines bearing a mutated R domain |
| 摘要 |
Diphtheria toxin polypeptides comprising a mutant R binding domain exhibit reduced target cell binding and may be used as vaccines to immunize a mammal against infection by Corynebacterium diphtheria.
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| 申请公布号 |
US5917017(A) |
申请公布日期 |
1999.06.29 |
| 申请号 |
US19940257781 |
申请日期 |
1994.06.08 |
| 申请人 |
PRESIDENT AND FELLOWS OF HARVARD COLLEGE;THE REGENTS OF THE UNIVERSITY OF CALIFORNIA |
发明人 |
COLLIER, R. JOHN;SHEN, WEI HAI;EISENBERG, DAVID;CHOE, SEUNGHYON |
| 分类号 |
C12N15/09;A61K39/00;A61K39/05;A61K47/48;A61P31/04;C07H21/04;C07K14/255;C07K14/34;C07K16/12;C07K19/00;C12N1/21;C12P21/02;C12P21/04;C12P21/08;C12R1/01;C12R1/07;C12R1/16;C12R1/19;C12R1/42;C12R1/63;(IPC1-7):C07K1/00;A61K39/08 |
主分类号 |
C12N15/09 |
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