New oxo dihydro isoquinoline propanamide derivatives having selective affinity for GABAergic sites

摘要

1-Oxo-1,2-dihydro isoquinoline-4-propanamide derivatives and intermediates are new. 1-Oxo-1,2-dihydro isoquinoline-4-propanamide derivatives of formula (I) are new. X = Me or MeO; R1 = Me; R2, R3 = H or 1-4C alkyl; or NR2R3 = pyrrolidinyl or piperidinyl; R4 = Me (optionally substituted by halo, MeO, CN, methylamino or 3-6C cycloalkyl), 2-4C alkyl or 2-4C alkenyl. An Independent claim is included for intermediates of formula (VII), as well as the corresponding acids.