STYELINS

摘要

Novel microbial peptides called styelins are of the formula J1-X2-X3-B'4-B"5-J6-X'7-B8-J9-X10 J11-Z12-X13-J*14-B*15-B16-B18-O19-J*20 X21-B22-J23-J24-X'25-C26-X*27-J28-X29-Z30 and the pharmaceutically acceptable acetylated forms and salts amides and esters thereof wherein: B represents a basic amino acid; B' represents a basic or a small amino acid; B" represents a basic amino acid or proline; B* represents a basic amino acid or tyrosine, wherein said tyrosine optionally is alkylated; X represents a hydrophobic amino acid; X' represents a hydrophobic or a small amino acid; Z represents a basic or a hydrophobic amino acid; J represents a small amino acid; J* represents a small amino acid or tyrosine which tyrosine is optionally methylated; O represents an amino acid containing a hydroxyl group; and C represents any amino acid.