USE OF AN AROMATASE INHIBITOR IN THE TREATMENT OF DECREASED ANDROGEN TO ESTROGEN RATIO AND DETRUSOR URETHRAL SPHINCTER DYSSYNERGIA IN MEN AND METHOD TO STUDY THE DYSSYNERGIA IN MALE RODENTS

摘要

The invention relates to the use of an aromatase inhibitor for the manufacture of a pharmaceutical composition to be used in the treatment of i) detrusor urethral sphincter dyssynergia in men, wherein said detrusor urethral sphincter dyssynergia is urethral dysfunction which is due to decreased androgen to estrogen ratio in the patient, or ii) decreased androgen to estrogen ratio in men. Furthermore, the invention also concerns a method for the in vivo investigation of the influence of a certain condition on the urinary function of male individuals using an animal model of male rodents wherein said rodents have been subjected to said condition, anesthetized, provided with a pressure transducer connected to an infusion cannula inserted in the bladder, a flow probe inserted in the distal urethra and connected to a flow meter, infused with a solution into the bladder to induce micturition, and wherein the bladder pressure and urinary flow are registered as function of time. According to the invention, electrodes are attached to muscles of the lower urinary tract. The electrical activity of said muscles are registered simultaneously with the registering of the bladder pressure and the urinary flow.