| 摘要 |
<p>A process for the preparation of an enantiomerically enriched 2-substituted succinic acid derivative of formula (2), comprises asymmetric hydrogenation of a dehydro precursor of formula (7) or (8), or a mixture thereof wherein R?1 and R2¿ are each independently H, a salt-forming cation or an organic group of up to 30 C atoms, and R?3 and R4¿ are each independently H or an organic group of up to 30 C atoms, or are linked to form a ring, provided that R?3 and R4¿ are not both H, in the presence of a transition metal complex of a chiral phosphine ligand having the partial formula (10) wherein n is 0 to 6 and R represents at least one non-hydrogen organic group of up to 30 C atoms.</p> |
