NOVEL MONOCLONAL ANTIBODIES AND UTILIZATION THEREOF

摘要

A monoclonal antibody having an affinity specifically with SSI-1 protein; a hybridoma producing this monoclonal antibody; a process for producing this hybridoma; a process for producing the monoclonal antibody involving the step of culturing the hybridoma either in vivo or in vitro; a method for assaying SSI-1 protein in samples characterized by using the monoclonal antibody; and a reagent containing the monoclonal antibody. Another monoclonal antibody having an affinity specifically with the SSI family; a hybridoma producing this monoclonal antibody; and utilization of the monoclonal antibody. These monoclonal antibodies make it possible to analyze various properties of SSI-1 protein and the SSI family. Moreover, they are usable as probes in studying molecular and physiological functions of these proteins. They are also applicable to the analysis of the intracellular signal transduction regulatory mechanism, usable in the fields of basic and clinical medicines, and useful in researches aiming at developing drugs and diagnostics, etc.