| 摘要 |
<p>The invention relates to complexes of cephradine and cefaclor and 1-naphthol. It has been found that 1-naphthol shows better complexing behaviour then for example 2-naphthol. The invention also relates to a process for the preparation of such complexes, the corresponding ß-lactam antibiotic being prepared through acylation of the corresponding ß-lactam nucleus with a suitable acylating agent and 1-naphthol being present in the reaction mixture during at least part of the acylation reaction. The acylation is preferably carried out in the presence of an enzyme. The ß-lactam antibiotic can subsequently be released from the complex in a known manner.</p> |
