QUINOLINEPIPERAZINE AND QUINOLINEPIPERIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS COMBINED 5-HT1A, 5-HT1B AND 5-HT1D RECEPTOR ANTAGONISTS

摘要

The invention relates to compounds of formula (I) or a salt thereof in which Ra is selected from a group of formula (i), (ii) or (iii); L is a group of formula -Y-C(=O)-DG- or -C(=O)-DG- or -DG-C(=O)- in which Y is -NH-, NR5 where R5 is C¿1-6?alkyl, or Y is -CH2- or -O-; D is nitrogen, carbon or a CH group, or G is hydrogen or C1-6alkyl providing that D is nitrogen or a CH group, or G together with R?b1¿ forms a group W where W is (CR16R17)t where t is 2, 3 or 4 and R?16 and R17¿ are independently hydrogen or C¿1-6?alkyl or W is (CR?16R17)¿u-J where u is 0, 1, 2 or 3 and J is oxygen, sulphur, CR?16=CR17, CR16=N, =CR16O, =CR16¿S or =CR16-NR17 provided that u is not 0 when J is oxygen or sulphur; X is nitrogen or carbon; R?b1, Rb2 and Rb3¿ are independently hydrogen, halogen, hydroxy, C¿1-6?alkyl, C2-6alkenyl, C3-6cycloalkyl, trifluoromethyl, C1-6alkoxy or aryl, or R?b1¿ together with G forms a group W as defined above; Rc is hydrogen or C¿1-6?alkyl; and ------- is a single bond when X is nitrogen or a single or double bond when X is carbon; having pharmacological activity, processes for their preparation, to compositions containing them and to their use in the treatment of CNS disorders.