发明名称 |
PHENYLAMINOALKYLCARBOXYLIC ACID DERIVATIVES AND MEDICINAL COMPOSITIONS CONTAINING THE SAME |
摘要 |
Novel phenylaminoalkylcarboxylic acid derivatives represented by general formula (I) and pharmacologically acceptable salts thereof, which have an excellent effect of stimulating beta 3-adrenergic receptor and are useful as preventives or remedies for obesity, hyperglycemia, diseases caused by accelerated intestinal motion, frequent urination or urinary incontinence, depression, cholelithiasis, diseases caused by accelerated biliary motion, etc. In said formula, R<1> represents hydroxy, lower alkyl, aralkoxy, amino, alicyclic amino optionally substituted by hydroxy or lower alkyl, or mono- or di(lower alkyl)amino; R<2> represents hydroxy or lower alkyl; R<3> represents hydrogen or halogeno; R<4> and R<5> represent each hydrogen, halogeno or lower alkyl; A represents lower alkylene; the carbon atom bearing the mark (R) is a carbon atom with the (R) configuration; and the carbon atom bearing the mark (S) is one with the (S) configuration.
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申请公布号 |
WO9931045(A1) |
申请公布日期 |
1999.06.24 |
申请号 |
WO1998JP05605 |
申请日期 |
1998.12.11 |
申请人 |
KISSEI PHARMACEUTICAL CO., LTD.;TAMAI, TETSURO;TANAKA, NOBUYUKI;MUKAIYAMA, HARUNOBU;HIRABAYASHI, AKIHITO;MURANAKA, HIDEYUKI;SATO, MASAAKI;AKAHANE, MASUO |
发明人 |
TAMAI, TETSURO;TANAKA, NOBUYUKI;MUKAIYAMA, HARUNOBU;HIRABAYASHI, AKIHITO;MURANAKA, HIDEYUKI;SATO, MASAAKI;AKAHANE, MASUO |
分类号 |
A61K31/165;A61K31/195;A61K31/215;A61P3/04;A61P3/10;A61P13/00;A61P25/24;C07C229/18;C07C237/06;C07D295/185;(IPC1-7):C07C229/18 |
主分类号 |
A61K31/165 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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