APOPTOSIS INHIBITORS

摘要

Apoptosis inhibitors containing as the active ingredient compounds represented by general formula (I) or salts thereof, wherein W1 represents -O-, -CH2-, etc.; W2 represents -CH2-, etc.; W3 represents -O-, -CH2-, etc.; X represents CH, C-, etc.; and A represents formula (.alpha.) wherein W4 represents -O-, CH2-, etc.; W5 represents -CH2-, etc.; and W6 represents -O-, -CH2-, etc. These apoptosis inhibitors inhibit apoptosis of WC8 cells induced by Fas ligand. In animal models, they potently inhibit the progress of fulminant hepatitis and relieve alopecia caused by anticancer agents. Because of being highly safe, these apoptosis inhibitors are usable as beneficial drugs.