| 摘要 |
4-Sulphonamido-benzopyran derivatives (I) are new. 4-Sulphonamido-benzopyran derivatives of formula (I) and their salts are new: R<1>, R<2> = H, CF3, C2F5, C3F7, alkyl, or phenyl optionally mono- or disubstituted; or R<1> + R<2> = alkylene; R<3> = R<10>-Cn-H2n-N(R<11>)- or R<10>-CnH2n- in which 1 CH2 is optionally replaced; R<4> = R<13>-CrH2r in which 1 CH2 is optionally replaced; or R<3> + R<4> = alkylene with 1 CH2 optionally replaced; n = 1-10; r = 1-20; R<10> = H, Me, cycloalkyl, CF3, C2F5, or C3F7; R<11> = H or alkyl; or R<10> + R<11> = a bond when n is at least 3; R<13> = Me, CF3, C2F5, C3F7, cycloalkyl, NR<15>R<16>, or phenyl or N-containing heterocyclyl (both optionally mono- or disubstituted); R<15>, R<16> = tetra- or pentamethylene in which 1 CH2 is optionally replaced); R<5> = Y-CsH2s-R <18> or phenyl (optionally mono- or disubstituted); Y = O, S or NR<1>0c; R10c = H or alkyl; s = 1-8; R<18> = H, CF<3>, C<2>F<5>, C<3>F<7>, cycloalkyl, COOR<21>, NR15aR16a, N-containing heterocyclyl, or phenyl or thienyl (both optionally mono- or disubstituted); or R15a + R16a = tetra- or pentamethylene in which 1 CH2 is optionally replaced); R<21> = H or alkyl; R<6> = OR10d or OCOR10d B = H; or R<6> + B = a bond; R10d = H or alkyl. The full definitions are given in the DEFINITIONS (Full Definitions) Field. Independent claims are also included for: (1) preparation of (I); (2) pharmaceutical compositions containing (I) and a beta-blocker. |
