DIAGNOSIS OF CLEAR CELL TYPE RENAL CARCINOMA

摘要

Method for detecting clear cell type renal carcinoma in a mammal comprising determining the concentration of Na,K-ATPase's beta -subunit in a biological sample. Alternatively the concentration of N-linked sugar residues, lactosamine residues, sialic acid residues, or combinations thereof in Na,K-ATPase's beta -subunit in the biological sample is determined and correlated with the presence of clear cell type renal carcinoma in the mammal. The method further includes detecting the Na,K-ATPase's spatial distribution in the tissue section by detecting the biological agent's spatial distribution in the tissue and correlating the Na,K-ATPase's spatial distribution in the tissue section to the presence of clear cell type renal carcinoma in the mammal. In addition, a kit for detecting clear cell type renal carcinoma is disclosed. The kit includes an agent capable of cleaving N-linked sugar residues, lactosamine residues, sialic acid, or combinations thereof and a biological agent which binds to Na,K-ATPase.