发明名称 |
Genteknologisk fremgangsmåde til fremstilling af S-(+)-2,2-dimethylcyclopropancarboxamid ved hjælp af mikroorganismer |
摘要 |
A genetic engineering process for the preparation of S-(+)-2,2-dimethylcyclopropanecarboxamide is described. For this, a DNA which codes for a stereospecific hydrolase is isolated from a microorganism. This DNA is then ligated into an expression vector, resulting in a hybrid plasmid which is transformed into microorganisms. These microorganisms are then capable of the biotransformation of the R-(-) isomer in racemic R,S-(+/-)-2,2-dimethylcyclopropanecarboxamide to the R-(-)-2,2-dimethylcyclopropanecarboxylic acid, resulting in optically active S-(+)-2,2-dimethylcyclopropanecarboxamide. <IMAGE> |
申请公布号 |
DK0524604(T3) |
申请公布日期 |
1999.06.23 |
申请号 |
DK19920112446T |
申请日期 |
1992.07.21 |
申请人 |
LONZA A.G. |
发明人 |
ZIMMERMANN, THOMAS, DR.;ROBINS, KAREN;BIRCH, OLWEN M.;BOEHLEN, ELISABETH |
分类号 |
C12P13/02;C07H21/00;C07K14/195;C12N1/00;C12N1/20;C12N1/21;C12N9/80;C12N11/06;C12N15/09;C12N15/11;C12N15/55;C12P7/40;C12P19/34;C12P41/00;C12R1/19;C12R1/38;C12R1/41 |
主分类号 |
C12P13/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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