| 摘要 |
<p>PCT No. PCT/SE94/00244 Sec. 371 Date Sep. 19, 1995 Sec. 102(e) Date Sep. 19, 1995 PCT Filed Mar. 18, 1994 PCT Pub. No. WO94/21286 PCT Pub. Date Sep. 29, 1994A solid pharmaceutical composition for oral administration of small and medium size peptides, particularly vasopressin, oxytocin, and their analogues, comprises the peptide, a protease inhibitor, an enteric coat and a pharmaceutically acceptable carrier containing a buffering agent buffering at a pH of from 3 to 6, preferably about pH 5. A method of manufacture of single doses of the peptide comprises mixing of the ingredients, forming the resulting mixture into spheres smaller than 2 mm, coating the spheres with an enteric coat which is readily soluble in gastric juice of pH 5.0 or higher but not at substantially lower pH, and filling the coated spheres in capsules or incorporating them into tablets, degradable in the stomach. Also disclosed is a method for oral administration to a patient of the single dose.</p> |
