CHROMENE-3-CARBOXYLATE DERIVATIVES

摘要

The present invention provides a compound of the formula (I): <CHEM> wherein R<1>, R<2>, R<3> and R<4> are each independently hydrogen, optionally substituted alkyl, hydroxy, optionally substituted alkoxy or the like, R<5> is optionally substituted alkyl, optionally substituted aryl, optionally substituted heterocyclic or the like, R<6> is hydrogen, optionally substituted alkyl or the like, R<7> is hydrogen, optionally substituted alkyl, optionally substituted alkoxy, optionally substituted aryl, optionally substituted heterocyclic or the like, A is S or O and a broken line represents presence or absence of a bond, pharmaceutically acceptable salt or hydrate thereof and a pharmaceutical composition or a pharmaceutical composition for use as an endothelin receptor antagonist, a peripheral circulation insufficiency-improving agent or a macrophage foam cell formation inhibitor comprising the compound.