发明名称 |
Antiviral activity and resolution of 2-hydroxymethyl-5-(5-fluorocytosin-1-yl)-1,3-oxathiolane |
摘要 |
A method and composition for the treatment of HIV and HBV infections in humans is disclosed that includes administering an effective amount of 2-hydroxymethyl-5-(5-fluorocytosin-1-yl)-1,3-oxathiolane, a pharmaceutically acceptable derivative thereof, including a 5' or N4 alkylated or acylated derivative, or a pharmaceutically acceptable salt thereof, in a pharmaceutically acceptable carrier. A process for the resolution of a racemic mixture of nucleoside enantiomers is also disclosed that includes the step of exposing the racemic mixture to an enzyme that preferentially catalyzes a reaction in one of the enantiomers.
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申请公布号 |
US5914331(A) |
申请公布日期 |
1999.06.22 |
申请号 |
US19950488097 |
申请日期 |
1995.06.07 |
申请人 |
EMORY UNIVERSITY |
发明人 |
LIOTTA, DENNIS C.;SCHINAZI, RAYMOND F.;CHOI, WOO-BAEG |
分类号 |
C07D327/04;C07D405/04;C07D411/04;C07H19/06;C07H19/10;(IPC1-7):A01N43/54;A61K31/70;C07D239/02 |
主分类号 |
C07D327/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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