METHOD OF PREPARING BETA-ANOMER ENRICHED NUCLEOSIDES

摘要

FIELD: chemical industry. SUBSTANCE: method of preparing beta-anomer enriched nucleosides of formula (I): wherein T is fluorine and R is nucleoside defined in claim 1. SN2 substitution is carried out optionally in suitable solvent of sulfonyloxy groups (IV) from monomer- enriched carbohydrate of formula (II): wherein X is independently selected from hydroxy protective groups, T is as defined above, by at least monomer equivalent of corresponding nucleobase at 17 to 120 C and deblocking is carried out to form compound of formula (I). Method is stereoselective. EFFECT: more efficient preparation method. 20 cl