NUCLEIC ACID CONSTRUCTS FOR GENE THERAPY WHOSE ACTIVITY IS AFFECTED BY INHIBITORS OF CYCLIN-DEPENDENT KINASES

摘要

The present application discloses nucleic acid constructs for the gene therapy of diseases, which constructs comprise nucleic acids which encode a protein which inhibits the cellular protein p27 and thereby relieves the inhibition of the proliferation of the cell which is brought about by p27, mutants thereof, some of which possess a dominant interfering character, and the use of these nucleic acids for the prophylaxis and therapy of diseases.