BINDING PARTNERS FOR INHIBITORS OF CYCLIN-DEPENDENT KINASES AND THEIR USE FOR SEARCHING FOR INHIBITORS AND FOR THE DIAGNOSIS OR THERAPY OF A DISEASE

摘要

The present application relates to a protein which inhibits the cellular protein p27 and thereby relieves the inhibition of the proliferation of the cell which is brought about by p27, mutants thereof, some of which possess a dominant interfering character, the corresponding nucleic acids which encode the protein and the use of proteins and nucleic acids for the prophylaxis and therapy of diseases. The application furthermore discloses nucleic acid constructs for the gene therapy of diseases, which constructs comprise the abovementioned nucleic acids.