发明名称 |
HUMANIZATION OF MURINE ANTIBODY |
摘要 |
A humanized murine antibody is provided. The amino acid sequences of a light chain complementarity determining region from a mouse antibody are grafted onto a human light chain, and a heavy chain complementarity determining region from a mouse antibody are grafted onto a human antibody heavy chain to produce libraries from which a humanized murine antibody having the desired specificity is selected.
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申请公布号 |
CA2312208(A1) |
申请公布日期 |
1999.06.17 |
申请号 |
CA19982312208 |
申请日期 |
1998.12.04 |
申请人 |
THE SCRIPPS RESEARCH INSTITUTE |
发明人 |
RADER, CHRISTOPH;BARBAS, CARLOS F., III |
分类号 |
C12N15/02;C07K16/00;C07K16/28;C07K16/46;C12P21/08;(IPC1-7):C12P21/08 |
主分类号 |
C12N15/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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