| 摘要 |
<p>The invention concerns dextran derivatives, their applications as medicines with specific biological action, and their preparation method. Said derivatives correspond to the general formula DMCaBbSUcSd, in which: D represents a polysaccharide chain, preferably consisting of sequences of glucoside units, MC represents methylcarboxylate groups, B represents carboxymethylbenzylamide groups, Su represents sulphate groups, S represents sulphonate groups, a, b, c and d represent the degree of substitution (ds), respectively in groups MC, B, Su and S; a being equal to 0 or ≥0.3, b being equal to 0 or ≥0.1, c being equal to 0 or ≥0.1 and d being equal to 0 or ≤0.15, provided that when d=0, a and/or b are not equal to 0, said products having homogeneity of chain size distribution, illustrated by a gaussian elution profile symmetrical in high performance steric exclusion chromatography, and homogeneity in the distribution of charged chemical groups, illustrated by an elution profile with a single symmetrical peak in low pressure ion-exchange chromatography.</p> |
