发明名称 PURINE COMPOUNDS HAVING PDE IV INHIBITORY ACTIVITY AND METHODS OF SYNTHESIS
摘要 <p>The present invention comprises compounds having general formula (I), wherein: Y1 is N or CH; Z is selected from the group consisting of alkyl groups such as alkylene groups such as CH2, CH2CH2, CH(CH3); alkenyl groups such as CH=CH; alkynyl groups such as C C; and NH, N(C1-C3 alkyl), O, S, C(O)CH2 and OCH2; R?1 and R2¿ are selected from the group consisting of hydrogen and a C¿1?-C8 straight or branched alkyl or a C3-C8 cycloalkyl; R?3¿ is a C¿1?-C12 straight or branched alkyl; R?4¿ is a C¿3?-C10 cycloalkyl optionally substituted with OH or C3-C10 cycloalkenyl optionally substituted with OH; and R?8¿ is a C¿1?-C8 straight or branched alkyl or a C3-C8 cycloalkyl, optionally substituted with OH; and methods of synthesis.</p>
申请公布号 WO1999029694(A1) 申请公布日期 1999.06.17
申请号 US1998026444 申请日期 1998.12.11
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