| 摘要 |
<p>Use is disclosed of a substantially non-aqueous composition comprising at least one membrane lipid and/or monoacyl derivative thereof suspended in a hydrophilic medium for the manufacture of a composition for application to the mucosa e.g. as a soothing, protective or lubricating agent. The composition can advantageously be used as a carrier for a medicament in molecular dispersion. A method is provided for preparing anti-fungal lipid-based compositions which can achieve high levels of entrapment of a drug and which are stable to storage but convert to liposomes, micelles or like structures in contact with the mucosa. Membrane lipid is dissolved in a first anhydrous organic liquid, for example ethanol, after which the drug is dissolved or dispersed in the resulting mixture and a second anhydrous organic liquid is added to form an anhydrous composition in which the lipid is at least partly in the form of solvate bilayers. A hydrocollid, hydrophilic polymer or natural gum may be present to render the composition more muco-adhesive. The method has particular value for the preparation of compositions containing miconazole, clotrimazole and amphotericin B.</p> |
