| 摘要 |
<p>The present invention is concerned with compounds of formula (I) the N-oxides, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein X represents O, S or NR3; R1 represents hydrogen, hydroxy, C¿1-6?alkyl or aryl; R?2¿ represents hydrogen; optionally substituted C¿1-12?alkyl; C3-7cycloalkyl; C2-8alkenyl; aryl; Het?1; or R1 and R2¿ taken together may form a bivalent radical of formula -(CH¿2?)n- wherein n is 2, 3, 4, 5 or 6; R?3¿ represents hydrogen, optionally substituted C¿1-6?alkyl, aryl, Het?1; R4¿ represents hydrogen; hydroxy; mercapto; C¿1-6?alkyloxy; C1-6alkylthio; aryloxy; arylthio; Het?1¿-oxy; Het1-thio; optionally substituted C¿1-12?alkyl; optionally substituted C2-8alkenyl; optionally substituted C2-8alkynyl; optionally substituted C3-7cycloalkyl; optionally substituted C5-7cycloalkenyl; aryl; Het?1¿; or -Alk-NR3R5 (i) or -NR3R5 (ii) wherein Alk represents C¿1-6?alkanediyl; and R?5¿ represents hydrogen, C¿1-6?alkyl, aryl, Het?1¿, (aryl or Het1)C1-6alkyl, (aryl or Het1)carbonyl or (aryl or Het1)C1-6alkyloxycarbonyl; aryl represents optionally substituted indanyl, indenyl, naphtyl, 5,6,7,8-tetrahydro-2-naphtalenyl or phenyl; Het represents an optionally substituted unsaturated heterocycle; and Het1 represents an optionally substituted monocyclic or bicyclic heterocycle; having retinoic mimetic activity; their preparation, compositions containing them and their use as a medicine.</p> |
