发明名称 |
CANCER SUSCEPTIBILITY MUTATIONS OF BRCA1 |
摘要 |
New mutations have been found in the BRCA1 gene. The mutations are located at nucleotide numbers 421-2, 815, 903, 926, 1506, 2034, 2428, 3888, 3904, 4164, 4643, 5053, 5150, 5210, or 5396+40 of the gene sequence of BRCA1. A process for identifying a sequence variation in a BRCA1 polynucleotide sequence is disclosed. The identification process includes allele specific sequence-based assays of known sequence variations. The methods can be used for efficient, and accurate detection of a mutation in a test BRCA1 gene sample. |
申请公布号 |
WO9929903(A2) |
申请公布日期 |
1999.06.17 |
申请号 |
WO1998US25916 |
申请日期 |
1998.12.07 |
申请人 |
GENE LOGIC |
发明人 |
OLSON, SHERI, J.;ANGELLY, TRACY, S.;LAWRENCE, TAMMY;LESCALLETT, JENNIFER, L.;MURPHY, PATRICIA, D.;ALLEN, ANTONETTE, P.;THURBER, DENISE, B.;WHITE, MARGA, B.;ZENG, BIN;SADZEWICZ, LISA, K. |
分类号 |
C12N15/09;C07K14/47;C12Q1/68 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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