发明名称 |
HIGH-AFFINITY TRYPTOPHAN TRANSPORTER |
摘要 |
A high-affinity and extremely selective tryptophan transport system present in human monocyte-derived macrophages is disclosed. Human monocyte-derived macrophages include two distinct transporters, a high-affinity (km=290 +/- 160 nM) transporter that is highly specific for tryptophan and a low affinity (km=27 +/- 4 mu M) transporter that is less specific for tryptophan, consistent with the known system L. The tryptophan transport system is predominantly (86 %) sodium-independent. The high-affinity system is very specific for tryptophan and shows no transport of any other essential amino acids in the tryptophan transport concentration range. This high-affinity system is expressed at very low levels in fresh monocytes, but undergoes a 10-30 fold induction during macrophage differentiation. This high-affinity, tryptophan-selective transport system allows macrophages to take up tryptophan efficiently under conditions of very low substrate concentration, such as can occur at sites of inflammation.
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申请公布号 |
WO9929852(A1) |
申请公布日期 |
1999.06.17 |
申请号 |
WO1998US25841 |
申请日期 |
1998.12.04 |
申请人 |
MEDICAL COLLEGE OF GEORGIA RESEARCH INSTITUTE, INC. |
发明人 |
MUNN, DAVID;MELLOR, ANDREW |
分类号 |
A61K31/405;A61K38/00;A61K38/19;A61K39/00;A61K48/00;C07K14/47;C12N15/12;(IPC1-7):C12N15/12;A01K67/027 |
主分类号 |
A61K31/405 |
代理机构 |
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代理人 |
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地址 |
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