PEPTIDE-BASED GEMINI COMPOUNDS

摘要

New peptide-based gemini compounds comprising two linked chains (a) each chain having: (1) a positively charged hydrophilic head, Q<1> or Q<2>, formed from one or more amino acids and/or amines, (2) a central portion, P<1> or P<2>, having a polypeptide backbone, and (3) a hydrophobic tail, R<1> or R<2>, the central sections of each chain being linked together by bridge Y through residues in P<1> and P<2>, are disclosed. Methods for their preparation and uses are also disclosed. Such uses include transfection of polynucleotides into cells in vivo and in vitro.