| 摘要 |
New peptide-based gemini compounds comprising two linked chains (a) each chain having: (1) a positively charged hydrophilic head, Q1 or Q2, formed from one or more amino acids and/or amines, (2) a central portion, P1 or P2, having a polypeptide backbone, and (3) a hydrophobic tail, R1 or R2, the central sections of each chain being linked together by bridge Y through residues in P1 and P2, are disclosed. Methods for their preparation and uses are also disclosed. Such uses include transfection of polynucleotides into cells in vivo and in vitro.
|
