| 摘要 |
PROBLEM TO BE SOLVED: To obtain a new deuterated ester compound useful as an intermediate for the production of 2,2-dideutero-5-aminolevulinic acid by introducing deuterium using inexpensive heavy water but not using a large excess amount of it. SOLUTION: This compound shown by the formula [R<1> is a 1-4C alkyl; R<2> forms a single bond together with R<3> ; R<4> is H] is obtained by the reaction of an allylmalonic acid ester with 1.0-1.5 equivalent(s) of a base (e.g. sodium hydroxicle, n-butyl lithium) in an appropriate solvent at -50 to 100 deg.C, followed by the reaction with 1.0-5 equivalent(s), preferably 1.0-2 equivalent(s), of heavy acetic acid prepared by adding 1/2 equivalent of heave water to acetic acid anhydride and stirring the mixture. |
