| 摘要 |
The effervescent mixture contains at least one acidic, insoluble or sparingly soluble pharmaceutical agent in the form of its soluble alkali metal salt or lysinate, which is present in intimate mixture with the alkaline component and preferably envelops the particles of the alkaline component of the effervescent system, e.g. sodium bicarbonate and/or sodium carbonate. Granules can also be produced from fine powders of the two constituents with the aid of a binder. The effervescent mixture contains, in particular, for 100 parts of agent at least 0.5, preferably 1 to 3, parts of a surfactant, in particular dioctyl sulphosuccinate, and/or at least 1, preferably 3 to 5, parts of a binding or suspending auxiliary, in particular polyvinylpyrrolidone. The acidic component of the effervescent system is surface-passivated. |
