USE OF ZONA PELLUCIDA GLYCOPROTEINS FOR IMMUNOCONTRACEPTION

摘要

A vaccine for the immunocontraception of mammals is described. The vaccine consi sts of zona pellucida antigens and an adjuvant encapsulated in a liposome delivery system. The liposome delivery syste m allows for the slow release of antigen resulting in a prolonged immune response. In particular, after a single injection of the v accine, levels of anti-zona pellucida antibodies were detected for up to 22 months. Thus, the vaccine according to the present in vention is effective after a single dose and is therefore very useful in immunocontraceptive protocols.