发明名称 |
A PROCESS TO STUDY CHANGES IN GENE EXPRESSION IN STEM CELLS |
摘要 |
The present invention includes a method to identify stem cell genes that are differentially expressed in stem cells at various stages of differentiation when compared to undifferentiated stem cells by preparing a gene expression profile of a stem cell population and comparing the profile to a profile prepared from stem cells at different stages of differentiation, thereby identifying cDNA species, and therefore genes, which are expressed. The present invention also includes methods to identify a therapeutic agent that modulates the expression of at least one stem cell gene associated with the differentiation, proliferation and/or survival of stem cells.
|
申请公布号 |
WO9910535(A9) |
申请公布日期 |
1999.06.03 |
申请号 |
WO1998US17283 |
申请日期 |
1998.08.21 |
申请人 |
YALE UNIVERSITY;LIU, MENG;BASKARAN, NAMADEV;WEISSMAN, SHERMAN, M. |
发明人 |
LIU, MENG;BASKARAN, NAMADEV;WEISSMAN, SHERMAN, M. |
分类号 |
C12N15/12;C12Q1/68;(IPC1-7):C12Q1/68 |
主分类号 |
C12N15/12 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|