发明名称 |
VACCINES WITH AN LTB ADJUVANT |
摘要 |
<p>The present invention relates to a vaccine containing at least one particulate immunogen and an adjuvanting amount of B subunits of heat-labile enterotoxin characteristic of E. Coli. More in particular, this invention relates to vaccines wherein the adjuvanting LTB is free from contaminating A subunits or holotoxin. To this end, preferably, use is made of LTB prepared by recombinant DNA techniques. The particulate immunogens can relate to or can be derived from e.g. viruses, bacteria or fungi. This vaccine is particularly suitable for the induction of a protective response against said particulate immunogen upon mucosal (e.g. intra-nasal) administration. It was found that such administration results in both systemic and mucosal protection against the pathogen to which the particulate immunogen relates.</p> |
申请公布号 |
CA2311492(A1) |
申请公布日期 |
1999.06.03 |
申请号 |
CA19982311492 |
申请日期 |
1998.11.24 |
申请人 |
DUPHAR INTERNATIONAL RESEARCH B.V.;UNIVERSITEIT VAN GRONINGEN |
发明人 |
BRANDS, RUDI;VERWEIJ, WILLEM RONALD;AGSTERIBBE, ETIENNE;DE HAAN, LOLKE;WILSCHUT, JAN CHRISTIAAN;VAN SCHARRENBURG, GUSTAAF JOHAN MARIE |
分类号 |
A61K38/00;A61K38/38;A61K39/00;A61K39/145;A61K39/39;A61P31/00;A61P31/16;A61P37/04;C07K14/11;C07K14/245;(IPC1-7):A61K39/39 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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