发明名称 |
DECREASING CELL PROLIFERATION BY DECREASING LEVELS OF PP5 |
摘要 |
The invention provides a method of increasing expression of p21WAF1/Cip 1 in cells to decrease proliferation of the cells, the method comprising decreasing levels of PP5 protein in the cells. The invention further provides a method of treating or preventing anabnormal condition resulting from a defect in a tumor suppressor gene in a subject that results in decreased induction of p21WAF1/Cip 1 in the cells of the subject, the method comprising administering to the subject an amount of a compound effective to decrease levels of PP5 protein in the cells of the subject.
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申请公布号 |
CA2309888(A1) |
申请公布日期 |
1999.06.03 |
申请号 |
CA19982309888 |
申请日期 |
1998.11.20 |
申请人 |
SOUTH ALABAMA MEDICAL SCIENCE FOUNDATION |
发明人 |
HONKANEN, RICHARD E. |
分类号 |
C12N15/09;A61K31/35;A61K31/711;A61K36/02;A61K48/00;A61P35/00;C07D519/00;C12N15/113;C12Q1/68;(IPC1-7):C12Q1/68;C07H21/04;C12N15/11;C12P19/34;C12N15/63;C12N15/85 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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