QUINOLINONE DERIVATIVE, METHOD FOR PREPARING THE SAME, AND ANTI-ALLERGIC AGENT

摘要

The present invention relates to a simple method for preparing a quinolinone derivative, which is effective as a medicine, e.g., as an agent for treating all ergic diseases and the like; novel amide derivatives effective as an intermediate in the method; no vel quinolinone derivatives obtained according to the method; and an anti-allergic a gent containing a quinolinone derivative and/or physiological salt of the same as the active ingredients. The quinolinone derivative is expressed by the following general fo rmula (II); and the method is characterized in that an amide derivative, expressed by the fo llowing general formula (I), is reacted with a basic agent, followed by intramolecular r ing formation: General Formula (I) (see fig. I) ¢wherein, R1 represents a hydrogen atom, an alkyl group, an alkyl group containi ng a hydroxyl group, an alkenyl group, or an aryl group; R2 represents an alkyl group , an alkenyl group, an aryl group, or an aralkyl group; R3 represents a reactive carboxyl gro up; and R4 to R7 represent, respectively and independently, a hydrogen atom, a hydroxyl group, an alkyl group, an alkoxy group, an alkenyl group, an alkenyloxy group, an aryl group, an aryloxy group, an aralkyloxy group, a R8R9N group (wherein, R8 and R9 represent, respect ively and independently, a hydrogen atom, an alkyl group, an alkenyl group, an aralkyl gro up, or an acyl group), a nitro group, or a R10OOC group (wherein, R10 represents a hydroge n atom, an alkyl group, an alkenyl group, an aryl group, or an aralkyl group)!. General Formula (II) (see fig. II) ¢wherein, R1, R2 and R4 to R7 represent, respectively, the same constituents as described in general formula (I)!.