| 发明名称 |
Process for the preparation of purified crystalline iohexol |
| 摘要 |
<p>Hydrophobic contaminants and residual organic solvents are removed from iohexol by the use of a fluid such as ethanol in which the iohexol is insoluble. In one procedure, ethanol is added to an aqueous solution of iohexol. In another procedure, the iohexol is suspended in ethanol and then allowed to crystallise. Crystalline iohexol having a residual solvent content below 100 ppm can be made in this way.</p> |
| 申请公布号 |
EP0919540(A1) |
申请公布日期 |
1999.06.02 |
| 申请号 |
EP19970308629 |
申请日期 |
1997.10.29 |
| 申请人 |
HOVIONE INTER LTD. |
发明人 |
DU BOULAY VILLAX, GUIDO;ALVAREZ PEREZ, CARLOS MANUEL;GANCHAS DE CARVALHO, ALEXANDRE JOSE |
| 分类号 |
A61K49/04;C07B63/00;C07C231/24;C07C237/46;(IPC1-7):C07C231/24 |
主分类号 |
A61K49/04 |
| 代理机构 |
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代理人 |
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| 地址 |
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