| 摘要 |
PCT No. PCT/EP92/02227 Sec. 371 Date Sep. 30, 1994 Sec. 102(e) Date Sep. 30, 1994 PCT Filed Sep. 28, 1992 PCT Pub. No. WO93/06066 PCT Pub. Date Apr. 1, 1993This invention describes a new methylation or ethylation agent containing trimethyl aluminum or dimethyl zinc or triethyl aluminum as methyl or ethyl source, which additionally contains catalytic amounts of one or more copper(I) and/or copper(II) compounds as well as a process for the 1,4-addition of a methyl or ethyl group to an alpha , beta -unsaturated or an alpha , beta -double unsaturated ketone or an alpha , beta -unsaturated aldehyde using the agent according to the invention. By using only catalytic amounts of copper and a CKW (chlorinatedhydrocarbon)-free reaction medium, the new methylation/ethylation agent/process is distinguished by its environmental compatibility and it is, for example, suitable for the production of initial products for the synthesis of biologically effective compounds.
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