5,10-dihydropyrimdo[4,5-b]quinolin-4(1H)-one tyrosine kinase inhibitors

摘要

PCT No. PCT/IB95/00172 Sec. 371 Date Aug. 22, 1997 Sec. 102(e) Date Aug. 22, 1997 PCT Filed Mar. 15, 1995 PCT Pub. No. WO96/28444 PCT Pub. Date Sep. 19, 1996Certain 5,10-dihydropyrimido[4,5-b]quinolin-4(1 H)-one compounds, and their pharmaceutically-acceptable salts, are useful as inhibitors of tyrosine kinase enzymes and for the treatment of tyrosine kinase dependent diseases (e.g., cancer, atherosclerosis, antiangiogenesis).