1,3,5 trisubstituted pyrazole compounds for treatment of inflammation

摘要

PCT No. PCT/US94/12722 Sec. 371 Date May 30, 1996 Sec. 102(e) Date May 30, 1996 PCT Filed Nov. 14, 1994 PCT Pub. No. WO95/15318 PCT Pub. Date Jun. 8, 1995A class of 1,3,5-substituted pyrazoles is described for the treatment of inflammation, including treatment of pain and disorders such as arthritis. Compounds of particular interest are of Formula I wherein R1, R2, R3 and R4 are as described herein; or a pharmaceutically-acceptable salt thereof.