发明名称 |
Synthetic peptide derivatives and the salts thereof |
摘要 |
The present invention provides synthetic peptide derivatives represented by the formulaP1-R1-P2wherein P1 is a peptide having an amino acid sequence in the SEQ ID NO.:1 of the Sequence Listing, or analogues thereof; P2 is a peptide having an amino acid sequence in the SEQ ID NO.:2 of the Sequence Listing, or analogues thereof; R1 denotes a linker with a property that does not interfere with the activity of the each peptide P1 and P2 to bind N-terminal end of the peptides P1 and P2. The present invention also provides a pharmaceutical composition for the treatment of bone related diseases comprising said peptide derivatives, or a therapeutically acceptable salt thereof, and a pharmaceutically acceptable carrier. The present invention also provides a method of treating bone related diseases in a mammal comprising administering thereto an effective amount of said peptide derivatives, or therapeutically acceptable salts thereof.
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申请公布号 |
US5908828(A) |
申请公布日期 |
1999.06.01 |
申请号 |
US19950497599 |
申请日期 |
1995.06.30 |
申请人 |
HOECHST JAPAN LIMITED |
发明人 |
KURITA, TAKASHI;MATSUMOTO, TOMOAKI;KIKUNO, REIKO;OTAWARA-HAMAMOTO, YOKO;BREIPOHL, GERHARD |
分类号 |
A61K38/00;C07K14/51;(IPC1-7):A61K38/16;C07K14/00 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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