发明名称 |
Method of using transdominant negative retroviral integrase in the treatment of retroviral infection |
摘要 |
A method of using a transdominant negative integrase gene to make at least one cell resistant to a retroviral infection which includes retroviral infections resulting from HIV; a method for introducing a transdominant negative integrase gene into at least one mammalian cell to make said cell resistant to a retroviral infection as well as vectors, cells, and methods of constructing same useful in the aforementioned methods; a method of treating AIDS comprising administering to a patient an effective amount of a transdominant negative integrase gene alone or combined with agents useful for gene therapy inhibition of HIV, antiviral agents, or interleukin-2; and pharmaceutical delivery methods which include a transdominant negative integrase gene alone or combined with agents useful for gene therapy inhibition of HIV, antiviral agents, or interleukin-2.
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申请公布号 |
US5908923(A) |
申请公布日期 |
1999.06.01 |
申请号 |
US19970841179 |
申请日期 |
1997.04.29 |
申请人 |
WARNER-LAMBERT COMPANY |
发明人 |
HOLLER, TOD PAUL;MEYER, ANNETTE;NABEL, GARY JAN;POST, LEONARD |
分类号 |
C12N15/09;A61K31/70;A61K35/76;A61K38/00;A61K38/55;A61K45/00;A61K48/00;A61P31/12;A61P37/04;A61P43/00;C07K14/16;C07K14/73;C12N5/00;C12N5/10;C12N7/00;C12N9/22;C12N15/55;C12R1/91;(IPC1-7):C07H21/04 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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