UREA 4-OXOCYCLIC COMPOUNDS, PHARMACEUTICAL COMPOSITION AND METHOD OF PATIENT TREATMENT

摘要

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to urea 4-oxocyclic compounds of the general formula (I) where X - unsaturated 6-membered carbocycle; R - optional covalent bond; Y - optional unsaturated 5-membered heterocycle or 6-membered carbocycle; when R is absent then X and Y are the condensed ring systems; when R - covalent bond then X and Y are ring systems bound through covalent bond; when Y is absent then R - covalent bond and X is bound with L through R; R1,R2 and R3 - chlorine, fluorine, bromine atoms, OH, alkyl-group independently or R1,R2,R3 are absent; L - alkylimino-group where its nitrogen atom is bound with nitrogen atom at position 1,4 of oxocyclic ring-component of urea; R4 - alkylene-group; A - alkyl or hydroxyalkyl, possibly substituted saturated 6-membered heterocycle or heteroalkyl containing two nitrogen atoms; R5 is -CH2-; or its pharmaceutically acceptable salts or esters. Compounds of the formula (I) or a pharmaceutical composition based on said can be used for treatment of human or other mammals suffering with cardiac arrhythmia and/or cardiac fibrillation. EFFECT: improved method of patient treatment, enhanced effectiveness of the composition. 10 cl, 25 ex