| 摘要 |
The invention relates to the use of derivatives of F-type prostaglandins as ocular hypotensives. The compounds used in accordance with the invention are represented by formula (I), wherein wavy line attachments indicate either the alpha ( alpha ) or beta ( beta ) configuration; hatched segments indicate alpha configuration; the solid triangle is used to indicate beta configuration; dashed bonds represent a double bond, or a single bond; R is a substituted heteroaryl radical having at least two pendant substituents selected from the group consisting of C1 to C6 alkyl; halogen; trifluoromethyl; COR<1>; COCF3; SO2NR<1>; NO2 and CN or at least one cyano group; R<1> is hydrogen or a lower alkyl radical having up to six carbon atoms, X is selected from the group consisting of -OR<1> and -N(R<1>)2; Y is = O or represents 2 hydrogen radicals and the 9, 11 or 15 lower alkyl esters thereof; provided, however, when said heteroaryl radical is a dichlorothienyl radical, the compound is not a 1-carboxylic acid or amide thereof. Certain of the compounds represented by Formula (I) are novel and comprise another aspect of the present invention.
|
