| 摘要 |
FIELD: organic chemistry, medicine, pharmacy. SUBSTANCE: invention describes new biologically active compounds of the formula (I): C<SB>2</SB>H<SB>5</SB>(ROCNH)CH(CH<SB>2</SB>)<SB>n</SB>-R<SB>1</SB> being when R is C<SB>6</SB>H<SB>5</SB> then R<SB>1</SB> is NC<SB>4</SB>H<SB>8</SB>O and n = 4, 6, 7; or R<SB>1</SB> is NC<SB>5</SB>H<SB>10</SB> and n = 5; or R<SB>1</SB> is NC<SB>6</SB>H<SB>12</SB> and n = 6; or R<SB>1</SB> is N(C<SB>4</SB>H<SB>9</SB>)<SB>2</SB> and n = 7; when R is C<SB>6</SB>H<SB>4</SB>Br-n then R<SB>1</SB> is N(C<SB>2</SB>H<SB>5</SB>)<SB>2</SB> and n = 4, 6, 7; or R<SB>1</SB> is NC<SB>5</SB>H<SB>10</SB> and n = 6, 7; or R<SB>1</SB> is NC<SB>4</SB>H<SB>8</SB>O and n = 7; or R<SB>1</SB> is N(C<SB>4</SB>H<SB>9</SB>)<SB>2</SB> and n = 7; when R is C<SB>6</SB>H<SB>4</SB>Cl-n then R<SB>1</SB> is N(CH<SB>3</SB>)<SB>2</SB> and n = 4; or R<SB>1</SB> is NC<SB>4</SB>H<SB>8</SB>O and n = 4; or R<SB>1</SB> is NC<SB>5</SB>H<SB>10</SB> and n = 7; when R is C<SB>6</SB>H<SB>4</SB>NO<SB>2</SB>-n then R<SB>1</SB> is N(C<SB>2</SB>H<SB>5</SB>)<SB>2</SB> and n = 7; when R is C<SB>6</SB>H<SB>4</SB>NO<SB>2</SB>-m, then R<SB>1</SB> is N(C<SB>2</SB>H<SB>5</SB>)<SB>2</SB> and n = 4, 7; or R<SB>1</SB> is NC<SB>4</SB>H<SB>8</SB>O and n = 6, 7; or R<SB>1</SB> is NC<SB>5</SB>H<SB>10</SB> and n = 6; when R is C<SB>4</SB>H<SB>4</SB>CH<SB>3</SB>-n then R<SB>1</SB> is NC<SB>4</SB>H<SB>8</SB>O and n = 6; or R<SB>1</SB> is NC<SB>5</SB>H<SB>10</SB> and n = 6; when R is C<SB>6</SB>H<SB>11</SB> then R<SB>1</SB> is NC<SB>4</SB>H<SB>8</SB>O and n = 6; or R<SB>1</SB> is NC<SB>5</SB>H<SB>10</SB> and n = 6; when R is 1-adamantyl then R<SB>1</SB> is NC<SB>4</SB>H<SB>8</SB>O and n = 6. Compounds show anti-arrhythmic, topical anesthetic and analgetic activities, they exhibit low toxicity and can be used in medicine. EFFECT: new bioactive compounds, low toxicity. 8 tbl, 27 ex
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