发明名称 |
NEW PROCESS |
摘要 |
The present invention relates to a novel process for the synthesis of 5-methoxy-2- [[(4-methoxy-3, 5-dimethyl-2- pyridinyl)methyl] sulfinyl]-1<u>H</u>- benzimidazole, known under the generic name omeprazole. Moreover, the present invention also relates to manufacture of a pharmaceutical preparation thereof and its use in medicine. The novel process for the preparation of omeprazole, comprises the step of oxidizing 5-methoxy-2- [[(4-methoxy-3, 5-dimethyl-2- pyridinyl) methyl]thio]-1<u>H</u>- benzimidazole in an organic solvent with an oxidizing agent in the presence of a titanium complex and optionally in the presence of a base.
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申请公布号 |
WO9925711(A1) |
申请公布日期 |
1999.05.27 |
申请号 |
WO1998SE01984 |
申请日期 |
1998.11.03 |
申请人 |
ASTRA AKTIEBOLAG;COTTON, HANNA;LARSSON, MAGNUS;MATTSON, ANDERS |
发明人 |
COTTON, HANNA;LARSSON, MAGNUS;MATTSON, ANDERS |
分类号 |
B01J31/22;A61K31/4439;A61P1/04;C07D401/12;(IPC1-7):C07D401/12 |
主分类号 |
B01J31/22 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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