METHOD OF PRODUCING L-ASPARTYL-D-ALANINE-N-(THIETHANE-3-YL)-AMIDES

摘要

PCT No. PCT/EP96/00393 Sec. 371 Date Nov. 21, 1997 Sec. 102(e) Date Nov. 21, 1997 PCT Filed Jan. 31, 1996 PCT Pub. No. WO96/26213 PCT Pub. Date Aug. 29, 1996The invention concerns a method of producing L-aspartyl-D-alanine-N-(thietane-3-yl) amides of general formula I by reacting D-alanine-thietane amides of general formula II with oxazolidinone compounds of general formula III in an inert organic solvent, wherein R1 stands for H or a selectively separable protective group, R2-R5 independently of one another, are identical or different and stand for H or linear or branched C1-C4-alkyl, and R6 and R7, independently of each other, are identical or different and stand for H, linear or branched C1-C4-alkyl, aryl or a group which activates the carbonyl group. (I) (II) (III)