| 摘要 |
PROBLEM TO BE SOLVED: To provide a method for industrially and efficiently produce 2, 6- diaminopurine-2'-deoxyriboside and 2-deoxyguanosine used as raw materials for medicaments such as antiviral agents, especially for anti-sense medicaments which especially become the topic of talks recently. SOLUTION: This production of the subject compounds is to (1) efficiently produce 2,6-diaminopurine-2'-deoxyriboside by acting 2'-deoxyribose-1-phosphoric acid or its salt and 2,6-diaminopurine to microorganisms, (2) produce 2,6- diaminopurine-2'-deoxyriboside by acting microorganisms to 2'-deoxyuridine or thymidine and 2,6-diaminopurine or its slt in the presence of inorganic phosphoric acid or its salt and (3) produce 2'-deoxyguanosine in high yield by acting an adenosine deaminase to 2,6-diaminopurine-2'-deoxyriboside as the substrate, which is produced and supplied at a stable cost by the methods (1) and (2). |
