| 摘要 |
PCT No. PCT/EP94/03295 Sec. 371 Date Apr. 3, 1996 Sec. 102(e) Date Apr. 3, 1996 PCT Filed Oct. 5, 1994 PCT Pub. No. WO95/09920 PCT Pub. Date Apr. 13, 1995A nucleotide sequence comprising a transcriptional regulatory sequence and a sequence contiguous therewith and under the transcriptional control thereof, which contiguous sequence encodes an RNA which consists of a plurality of sub-sequences, characterized in that at least two of the sub-sequences have the sequences of viral RNAs and the RNA contains at least one translational stop codon located upstream of the 3' terminal sub-sequence. It is preferred that at least one of the sub-sequences is in an anti-sense configuration with respect to virus RNA, and that the contiguous sequence encodes mRNA. The invention also includes, inter alia, the use of such a sequence in the generation of virus resistant or tolerant plants, and such plants comprising the sequence.
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